It is based off Isesaki Commercial High School in the Gunma prefecture, being the high school that Keiichi Arawi (Nichijou's creator) attended.
- (62 yo) Principal: Principal Shinonome
- (59 yo) Vice Principal: Kousuke Oura
- (24 yo) English Teacher / 1Q Homeroom Teacher: Izumi Sakurai
- (26 yo) Japanese Teacher / 1B Homeroom Teacher: Manabu Takasaki
- (24 yo) Science Teacher: Kana Nakamura
- (38 yo) Math Teacher: Akagi
- (54 yo) History Teacher: Tomioka
- Unknown Teacher (with glasses)
The class where the "Tests are over" short takes place. No known characters are in this class.
This is the class where majority of the casts study in.
This is the class where Ogi studies.
Science Preparation Room
This room is used by Nakamura, and she is usually seen scheming on how to capture and examine Nano, occasionally trying to capture her in the room.